Vedolizumab

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4950
R12981		 Moens (Controls exposed to TNFi), 2020 Congenital anomalies (NOS) at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.94 [0.42;8.93] C
excluded (control group) 		3/64   4/162 7 64
ref
S4946
R12975		 Moens (Controls unexposed, sick), 2020 Congenital anomalies (NOS) at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 2.62 [0.52;13.35] C 3/64   3/163 6 64
ref
Total 1 studies 2.62 [0.52;13.35] 6 64
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Moens (Controls unexposed, sick), 2020Moens, 2020 1 2.62[0.52; 13.35]6640%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.62[0.52; 13.35]664 -NAMoens (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.62[0.52; 13.35]664 -NAMoens (Controls unexposed, sick), 2020 1 Tags Adjustment   - No  - No 2.62[0.52; 13.35]664 -NAMoens (Controls unexposed, sick), 2020 1 All studiesAll studies 2.62[0.52; 13.35]664 -NAMoens (Controls unexposed, sick), 2020 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4950

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.62[0.52; 13.35]664 -NAMoens (Controls unexposed, sick), 2020 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.94[0.42; 8.93]764 -NAMoens (Controls exposed to TNFi), 2020 10.510.01.0