Natalizumab

Neuro-developmental disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3777
R8075		 Portaccio (control unexposed, sick), 2018 Developmental abnormalities early pregnancy prospective cohort unexposed, sick Adjustment: No 6.37 [0.88;46.18] C 2/54   2/333 4 54
ref
Total 1 studies 6.37 [0.88;46.18] 4 54
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Portaccio (control unexposed, sick), 2018Portaccio, 2018 1 6.37[0.88; 46.18]4540%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 6.37[0.88; 46.18]454 -NAPortaccio (control unexposed, sick), 2018 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 6.37[0.88; 46.18]454 -NAPortaccio (control unexposed, sick), 2018 1 Tags Adjustment   - No  - No 6.37[0.88; 46.18]454 -NAPortaccio (control unexposed, sick), 2018 1 All studiesAll studies 6.37[0.88; 46.18]454 -NAPortaccio (control unexposed, sick), 2018 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 6.37[0.88; 46.18]454 -NAPortaccio (control unexposed, sick), 2018 10.510.01.0