Natalizumab

Ectopic pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3778
R8081		 Portaccio (control exposed to IFN), 2018 Extra-uterine pregnancy early pregnancy prospective cohort unexposed, sick Adjustment: No 1.28 [0.03;65.21] C 0/69   0/88 0 69
ref
S3777
R8069		 Portaccio (control unexposed, sick), 2018 Extra-uterine pregnancy early pregnancy prospective cohort unexposed, sick excluded Adjustment: No 0.99 [0.05;20.82] C
excluded (control group) 		0/69   2/341 2 69
ref
Total 1 studies 1.28 [0.03;65.21] 0 69
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Portaccio (control exposed to IFN), 2018Portaccio, 2018 1 1.28[0.03; 65.21]0690%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control exposed to IFN;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.28[0.03; 65.21]-69 -NAPortaccio (control exposed to IFN), 2018 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.28[0.03; 65.21]-69 -NAPortaccio (control exposed to IFN), 2018 1 Tags Adjustment   - No  - No 1.28[0.03; 65.21]-69 -NAPortaccio (control exposed to IFN), 2018 1 All studiesAll studies 1.28[0.03; 65.21]-69 -NAPortaccio (control exposed to IFN), 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3777

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.09[0.10; 12.10]21380%NAPortaccio (control exposed to IFN), 2018 Portaccio (control unexposed, sick), 2018 20.510.01.0