Natalizumab

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3656
R7597		 Nguyen (control exposed to IFN), 2019 Induced abortion during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 3.16 [1.47;6.77] C
excluded (control group) 		13/78   18/302 31 78
ref
S3657
R7600		 Nguyen (control unexposed, sick), 2019 Induced abortion during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 5.45 [2.68;11.07] C 13/78   27/763 40 78
ref
S3778
R8080		 Portaccio (control exposed to IFN), 2018 Voluntary abortions early pregnancy prospective cohort unexposed, sick Adjustment: No 0.75 [0.17;3.27] C 3/69   5/88 8 69
ref
S3777
R8068		 Portaccio (control unexposed, sick), 2018 Voluntary abortions early pregnancy prospective cohort unexposed, sick excluded Adjustment: No 36.39 [1.86;712.87] C
excluded (control group) 		3/69   0/341 3 69
ref
S3770
R8055		 Ebrahimi (control unexposed, disease free), 2015 Terminations (NOS) 3 months or more before pregnancy or1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 2.04 [0.37;11.42] C
excluded (control group) 		4/98   2/98 6 98
ref
S3769
R8048		 Ebrahimi (control unexposed, sick), 2015 Terminations (NOS) 3 months or more before pregnancy or1st trimester excluded prospective cohort unexposed, sick Adjustment: No 0.63 [0.17;2.31] C
excluded (exposition period) 		4/98   6/95 10 98
ref
Total 2 studies 2.26 [0.33;15.52] 48 147
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nguyen (control unexposed, sick), 2019Nguyen, 2019 1 5.45[2.68; 11.07]407855%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Portaccio (control exposed to IFN), 2018Portaccio, 2018 2 0.75[0.17; 3.27]86945%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 82% 2.26[0.33; 15.52]481470.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control exposed to IFN;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.26[0.33; 15.52]4814782%NANguyen (control unexposed, sick), 2019 Portaccio (control exposed to IFN), 2018 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.26[0.33; 15.52]4814782%NANguyen (control unexposed, sick), 2019 Portaccio (control exposed to IFN), 2018 2 Tags Adjustment   - No  - No 2.26[0.33; 15.52]4814782%NANguyen (control unexposed, sick), 2019 Portaccio (control exposed to IFN), 2018 2 All studiesAll studies 2.26[0.33; 15.52]4814782%NANguyen (control unexposed, sick), 2019 Portaccio (control exposed to IFN), 2018 20.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3770, 3777, 3656

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 3.92[0.70; 22.03]5121674%NANguyen (control unexposed, sick), 2019 Portaccio (control exposed to IFN), 2018 Portaccio (control unexposed, sick), 2018 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.16[1.47; 6.77]3178 -NANguyen (control exposed to IFN), 2019 10.510.01.0