Diuretics (versus unexposed) updated on 03-11-2025

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17121
R71666		 Van der Zande - Diuretics, 2024 Pre-eclampsia and HELLP syndrome 1st trimester prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 0.37 [0.09;1.49] C 2/191   150/5,357 152 191
ref
S13514
R52206		 Mabie - Hydrochlorothiazide, 1986 Superimposed preeclampsia during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only chronic hypertension indication 0.57 [0.11;2.88] C 2/10   25/82 27 10
ref
Total 2 studies 0.44 [0.15;1.28] 179 201
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Van der Zande - Diuretics, 2024Van der Zande - Diuretics, 2024 0.37[0.09; 1.49]15219157%ROB confusion: criticalROB selection: lowROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate Mabie - Hydrochlorothiazide, 1986Mabie - Hydrochlorothiazide, 1986 0.57[0.11; 2.88]271043%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.44[0.15; 1.28]1792010.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.44[0.15; 1.28]1792010%NAVan der Zande - Diuretics, 2024 Mabie - Hydrochlorothiazide, 1986 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.44[0.15; 1.28]1792010%NAVan der Zande - Diuretics, 2024 Mabie - Hydrochlorothiazide, 1986 2 Tags Adjustment   - No  - No 0.44[0.15; 1.28]1792010%NAVan der Zande - Diuretics, 2024 Mabie - Hydrochlorothiazide, 1986 2 Indications Antihypertensive   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 0.37[0.09; 1.49]152191 -NAVan der Zande - Diuretics, 2024 1   - Only chronic hypertension indication  - Only chronic hypertension indication 0.57[0.11; 2.88]2710 -NAMabie - Hydrochlorothiazide, 1986 1 All studiesAll studies 0.44[0.15; 1.28]1792010%NAVan der Zande - Diuretics, 2024 Mabie - Hydrochlorothiazide, 1986 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.44[0.15; 1.28]1792010%NAVan der Zande - Diuretics, 2024 Mabie - Hydrochlorothiazide, 1986 20.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Churchill (Hypertension (new or worsening))Churchill (Hypertension (new or worsening)) 0.85[0.68; 1.08]65%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT2 Churchill (Pre-eclampsia)Churchill (Pre-eclampsia) 0.68[0.45; 1.03]43%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT4 Bellos - Furosemide (Preeclampsia (Randomized ...Bellos - Furosemide (Preeclampsia (Randomized controlled trial and Cohort studies)) 1.52[0.32; 7.17]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Bellos - Furosemide (Preeclampsia (Randomized ...Bellos - Furosemide (Preeclampsia (Randomized controlled trial only)) 1.40[0.20; 9.91]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Churchill (Severe pre-eclampsia)Churchill (Severe pre-eclampsia) 1.56[0.26; 9.17]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT1 metaPregmetaPreg Out of scale0.44[0.15; 1.28]0%201----Van der Zande - Diuretics, 2024 Mabie - Hydrochlorothiazide, 1986 20.510.01.0