Diuretics (versus unexposed) updated on 03-11-2025

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14254
R56048		 Fisher - Diuretics (Controls unexposed, disease free), 2017 Perimembranous Ventricular septal defect (VSD) early pregnancy case control unexposed, disease free excluded Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 2.63 [0.43;12.33]
excluded (control group) 		3/-   -/- - -
ref
S14256
R56058		 Fisher - Diuretics (Controls unexposed, sick), 2017 Perimembranous Ventricular septal defect (VSD) early pregnancy case control unexposed, sick Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 2.00 [0.32;9.50] 3/-   -/- - -
ref
Total 1 studies 2.00 [0.37;10.90] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fisher - Diuretics (Controls unexposed, sick), 2017Fisher - Diuretics, 2017 1 2.00[0.32; 9.50]--0%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.00[0.37; 10.90]-- -NAFisher - Diuretics (Controls unexposed, sick), 2017 1 Type of controls unexposed, sickunexposed, sick 2.00[0.37; 10.90]-- -NAFisher - Diuretics (Controls unexposed, sick), 2017 1 Tags Adjustment   - No  - No 2.00[0.37; 10.90]-- -NAFisher - Diuretics (Controls unexposed, sick), 2017 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.00[0.37; 10.90]-- -NAFisher - Diuretics (Controls unexposed, sick), 2017 1 All studiesAll studies 2.00[0.37; 10.90]-- -NAFisher - Diuretics (Controls unexposed, sick), 2017 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 14254

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.63[0.49; 14.08]-- -NAFisher - Diuretics (Controls unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls 2.00[0.37; 10.90]-- -NAFisher - Diuretics (Controls unexposed, sick), 2017 10.510.01.0