Diuretics (versus unexposed) updated on 03-11-2025

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17121
R71682		 Van der Zande - Diuretics, 2024 Neonatal mortality (death of a live-born baby within the first month of life) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 1.94 [0.68;5.56] C 4/382   29/5,357 33 382
ref
Total 1 studies 1.94 [0.68;5.56] 33 382
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Van der Zande - Diuretics, 2024Van der Zande - Diuretics, 2024 1.94[0.68; 5.56]333820%ROB confusion: criticalROB selection: lowROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.94[0.68; 5.56]33382 -NAVan der Zande - Diuretics, 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.94[0.68; 5.56]33382 -NAVan der Zande - Diuretics, 2024 1 Tags Adjustment   - No  - No 1.94[0.68; 5.56]33382 -NAVan der Zande - Diuretics, 2024 1 Indications Antihypertensive   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 1.94[0.68; 5.56]33382 -NAVan der Zande - Diuretics, 2024 1 All studiesAll studies 1.94[0.68; 5.56]33382 -NAVan der Zande - Diuretics, 2024 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.94[0.68; 5.56]33382 -NAVan der Zande - Diuretics, 2024 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Churchill (Neonatal death)Churchill (Neonatal death) 0.88[0.40; 1.97]0%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT4 metaPregmetaPreg 1.94[0.68; 5.56]NaN%382----Van der Zande - Diuretics, 2024 10.510.01.0