Diuretics (versus unexposed) updated on 03-11-2025

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17121
R71677		 Van der Zande - Diuretics, 2024 Apgar score <7 at 5 min during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 1.74 [1.24;2.44] C 42/382   355/5,357 397 382
ref
S14169
R55571		 Sibai - Diuretics, 1984 5-min Apgar Score <7 throughout pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: Only chronic hypertension indication 3.35 [0.12;93.84] C 1/10   0/10 1 10
ref
Total 2 studies 1.75 [1.25;2.45] 398 392
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Van der Zande - Diuretics, 2024Van der Zande - Diuretics, 2024 1.74[1.24; 2.44]39738299%ROB confusion: criticalROB selection: lowROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate Sibai - Diuretics, 1984Sibai - Diuretics, 1984 3.35[0.12; 93.84]1101%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.75[1.25; 2.45]3983920.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.74[1.24; 2.44]397382 -NAVan der Zande - Diuretics, 2024 1 case control studiescase control studies 0 RCTRCT 3.35[0.12; 93.84]110 -NASibai - Diuretics, 1984 1 Type of controls unexposed, sickunexposed, sick 1.75[1.25; 2.45]3983920%NAVan der Zande - Diuretics, 2024 Sibai - Diuretics, 1984 2 Tags Adjustment   - No  - No 1.74[1.24; 2.44]397382 -NAVan der Zande - Diuretics, 2024 1   - Randomisation  - Randomisation 3.35[0.12; 93.84]110 -NASibai - Diuretics, 1984 1 Indications Antihypertensive   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 1.74[1.24; 2.44]397382 -NAVan der Zande - Diuretics, 2024 1   - Only chronic hypertension indication  - Only chronic hypertension indication 3.35[0.12; 93.84]110 -NASibai - Diuretics, 1984 1 All studiesAll studies 1.75[1.25; 2.45]3983920%NAVan der Zande - Diuretics, 2024 Sibai - Diuretics, 1984 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.75[1.25; 2.45]3983920%NAVan der Zande - Diuretics, 2024 Sibai - Diuretics, 1984 20.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Churchill (Apgar score at 5 minutes less than 7)Churchill (Apgar score at 5 minutes less than 7) 3.00[0.14; 65.90]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT1 metaPregmetaPreg 1.75[1.25; 2.45]0%392----Van der Zande - Diuretics, 2024 Sibai - Diuretics, 1984 20.510.01.0