Diuretics (versus unexposed) updated on 03-11-2025

Central Nervous System (CNS) tumors

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14141
R55472		 McCredie - Diuretics, 1994 Childhood brain tumour (primary malignant tumour of the brain (ICD-9 191) or cranial nerves (ICD-9 192.0) - At 0-14 years old during pregnancy (anytime or not specified) case control unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified Matched 0.50 [0.10;4.40] 1/5   81/241 82 5
ref
Total 1 studies 0.50 [0.08;3.32] 82 5
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF McCredie - Diuretics, 1994McCredie - Diuretics, 1994 0.50[0.10; 4.40]8250%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.50[0.08; 3.32]825 -NAMcCredie - Diuretics, 1994 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.50[0.08; 3.32]825 -NAMcCredie - Diuretics, 1994 1 Tags Adjustment   - Yes  - Yes 0.50[0.08; 3.32]825 -NAMcCredie - Diuretics, 1994 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 0.50[0.08; 3.32]825 -NAMcCredie - Diuretics, 1994 1 MatchedMatched 0.50[0.08; 3.32]825 -NAMcCredie - Diuretics, 1994 1 All studiesAll studies 0.50[0.08; 3.32]825 -NAMcCredie - Diuretics, 1994 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.50[0.08; 3.32]825 -NAMcCredie - Diuretics, 1994 10.510.01.0