Diuretics (versus unexposed) updated on 03-11-2025

Macrosomia (> 4000g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14087
R55435		 Olesen_Denmark - Diuretics, 2001 High birth weight (birth weight above 4000 g) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 1.10 [0.80;1.40] 63/315   8,957/46,998 9,020 315
ref
S14088
R55439		 Olesen_Scotland - Diuretics, 2001 High birth weight (birth weight above 4000 g) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 0.70 [0.30;1.60] 7/73   4,509/35,798 4,516 73
ref
Total 2 studies 1.05 [0.80;1.37] 13,536 388
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Olesen_Denmark - Diuretics, 2001Olesen_Denmark - Diuretics, 2001 1.10[0.80; 1.40]9,02031590%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Olesen_Scotland - Diuretics, 2001Olesen_Scotland - Diuretics, 2001 0.70[0.30; 1.60]4,5167310%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 1% 1.05[0.80; 1.37]13,5363880.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.05[0.80; 1.37]13,5363881%NAOlesen_Denmark - Diuretics, 2001 Olesen_Scotland - Diuretics, 2001 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.05[0.80; 1.37]13,5363881%NAOlesen_Denmark - Diuretics, 2001 Olesen_Scotland - Diuretics, 2001 2 Tags Adjustment   - Yes  - Yes 1.05[0.80; 1.37]13,5363881%NAOlesen_Denmark - Diuretics, 2001 Olesen_Scotland - Diuretics, 2001 2 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.05[0.80; 1.37]13,5363881%NAOlesen_Denmark - Diuretics, 2001 Olesen_Scotland - Diuretics, 2001 2 All studiesAll studies 1.05[0.80; 1.37]13,5363881%NAOlesen_Denmark - Diuretics, 2001 Olesen_Scotland - Diuretics, 2001 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.05[0.80; 1.37]13,5363881%NAOlesen_Denmark - Diuretics, 2001 Olesen_Scotland - Diuretics, 2001 20.510.01.0