Carbimazole, Thiamazole (Methimazole)

Neuro-developmental disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3429
R6374		 McCarroll (Buckinghamshire control group), 1976 4 or more behavioural problems throughout pregnancy retrospective cohort unexposed, disease free Adjustment: No 5.34 [2.17;13.10] C 8/20   684/6,160 692 20
ref
S3428
R6373		 McCarroll (Northern Ireland control group), 1976 4 or more behavioural problems throughout pregnancy retrospective cohort unexposed, disease free excluded Adjustment: No 1.56 [0.42;5.76] C
excluded (control group) 		8/20   6/20 14 20
ref
Total 1 studies 5.34 [2.17;13.10] 692 20
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF McCarroll (Buckinghamshire control group), 1976McCarroll, 1976 1 5.34[2.17; 13.10]692200%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Buckinghamshire control group;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.34[2.17; 13.10]69220 -NAMcCarroll (Buckinghamshire control group), 1976 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.34[2.17; 13.10]69220 -NAMcCarroll (Buckinghamshire control group), 1976 1 Tags Adjustment   - No  - No 5.34[2.17; 13.10]69220 -NAMcCarroll (Buckinghamshire control group), 1976 1 All studiesAll studies 5.34[2.17; 13.10]69220 -NAMcCarroll (Buckinghamshire control group), 1976 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3428

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.17[0.96; 10.46]7064057%NAMcCarroll (Buckinghamshire control group), 1976 McCarroll (Northern Ireland control group), 1976 20.510.01.0