Carbimazole, Thiamazole (Methimazole)

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3563
R7097		 Gianetti (control exposed to PTU), 2015 Preeclampsia at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.42 [0.01;21.30] C
excluded (control group) 		0/124   0/52 0 124
ref
S3562
R7086		 Gianetti (control unexposed, sick), 2015 Preeclampsia at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.54 [0.02;13.46] C 0/124   1/203 1 124
ref
Total 1 studies 0.54 [0.02;13.46] 1 124
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 0.54[0.02; 13.46]11240%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.54[0.02; 13.46]1124 -NAGianetti (control unexposed, sick), 2015 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.54[0.02; 13.46]1124 -NAGianetti (control unexposed, sick), 2015 1 Tags Adjustment   - No  - No 0.54[0.02; 13.46]1124 -NAGianetti (control unexposed, sick), 2015 1 All studiesAll studies 0.54[0.02; 13.46]1124 -NAGianetti (control unexposed, sick), 2015 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3563

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.54[0.02; 13.46]1124 -NAGianetti (control unexposed, sick), 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.42[0.01; 21.30]-124 -NAGianetti (control exposed to PTU), 2015 10.510.01.0