Carbimazole, Thiamazole (Methimazole)

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8483
R27808		 Yoshihara (Controls exposed to PTU), 2021 Ventricular septal defect 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 2.65 [0.14;50.72] C
excluded (control group) 		0/23   4/541 4 23
ref
S8482
R27786		 Yoshihara (Controls unexposed, sick), 2021 Ventricular septal defect 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.90 [0.10;35.38] C 0/23   5/475 5 23
ref
S3353
R5974		 Yoshihara (control exposed to PTU), 2012 Ventricular septal defect 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.28 [0.49;3.33] C
excluded (control group) 		9/1,231   8/1,399 17 1,231
ref
S3350
R5835		 Yoshihara (control unexposed, sick), 2012 Ventricular septal defect 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.27 [0.52;3.07] C 9/1,231   11/1,906 20 1,231
ref
Total 2 studies 1.31 [0.56;3.06] 25 1,254
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (Controls unexposed, sick), 2021Yoshihara, 2021 1 1.90[0.10; 35.38]5238%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 1.27[0.52; 3.07]201,23192%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.31[0.56; 3.06]251,2540.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.31[0.56; 3.06]251,2540%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.31[0.56; 3.06]251,2540%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 Tags Adjustment   - No  - No 1.31[0.56; 3.06]251,2540%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 All studiesAll studies 1.31[0.56; 3.06]251,2540%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3353, 8483

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.31[0.56; 3.06]251,2540%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.37[0.55; 3.41]211,2540%NAYoshihara (Controls exposed to PTU), 2021 Yoshihara (control exposed to PTU), 2012 20.510.01.0