Carbimazole, Thiamazole (Methimazole)

Cardiac septal defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3575
R7138		 Andersen 2014 (control unexposed, disease free), 2014 Cardiac septa early pregnancy population based cohort retrospective unexposed, disease free Adjustment: Yes 1.87 [1.14;3.05] -/1,097   -/811,730 - 1,097
ref
S3386
R6301		 Korelitz (control exposed to PTU), 2013 Atrial or ventricular septal heart defects (ASD/VSD) 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.65 [0.08;5.01] C
excluded (control group) 		1/108   13/915 14 108
ref
S3384
R6285		 Korelitz (control unexposed, disease free), 2013 Atrial or ventricular septal heart defects (ASD/VSD) 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 0.74 [0.10;5.27] C
excluded (control group) 		1/108   7,970/634,858 7,971 108
ref
S3385
R6293		 Korelitz (control unexposed, sick), 2013 Atrial or ventricular septal heart defects (ASD/VSD) 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 0.71 [0.10;5.21] C
excluded (exposition period) 		1/108   42/3,236 43 108
ref
Total 1 studies 1.87 [1.14;3.06] 0 1,097
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen 2014 (control unexposed, disease free), 2014Andersen 2014, 2014 1 1.87[1.14; 3.05]-1,0970%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.87[1.14; 3.06]-1,097 -NAAndersen 2014 (control unexposed, disease free), 2014 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.87[1.14; 3.06]-1,097 -NAAndersen 2014 (control unexposed, disease free), 2014 1 Tags Adjustment   - Yes  - Yes 1.87[1.14; 3.06]-1,097 -NAAndersen 2014 (control unexposed, disease free), 2014 1 All studiesAll studies 1.87[1.14; 3.06]-1,097 -NAAndersen 2014 (control unexposed, disease free), 2014 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3386, 3384

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.87[1.14; 3.06]-1,097 -NAAndersen 2014 (control unexposed, disease free), 2014 10.510.01.0