Carbimazole, Thiamazole (Methimazole)

Ear malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3337
R5703		 Andersen 2017 (control exposed to PTU), 2017 Ear early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.27 [0.01;5.60] C
excluded (control group) 		0/162   2/218 2 162
ref
S3335
R5668		 Andersen 2017 (control unexposed, disease free), 2017 Ear early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 1.81 [0.11;29.05] C
excluded (control group) 		0/162   1,166/682,343 1,166 162
ref
S3336
R5682		 Andersen 2017 (control unexposed, sick), 2017 Ear early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 9.60 [0.19;485.50] C 0/162   0/1,551 0 162
ref
Total 1 studies 9.60 [0.19;485.50] 0 162
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 1 9.60[0.19; 485.50]01620%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 9.60[0.19; 485.50]-162 -NAAndersen 2017 (control unexposed, sick), 2017 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 9.60[0.19; 485.50]-162 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 9.60[0.19; 485.50]-162 -NAAndersen 2017 (control unexposed, sick), 2017 1 All studiesAll studies 9.60[0.19; 485.50]-162 -NAAndersen 2017 (control unexposed, sick), 2017 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3337, 3335

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.81[0.11; 29.05]1,166162 -NAAndersen 2017 (control unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls 9.60[0.19; 485.50]-162 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.27[0.01; 5.60]2162 -NAAndersen 2017 (control exposed to PTU), 2017 10.510.01.0