Carbimazole, Thiamazole (Methimazole)

Situs inversus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3353
R5979		 Yoshihara (control exposed to PTU), 2012 Situs inversus (complete and viscerum) 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.23 [0.01;4.73] C
excluded (control group) 		0/1,231   2/1,399 2 1,231
ref
S3350
R5842		 Yoshihara (control unexposed, sick), 2012 Situs inversus (complete and viscerum) 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.55 [0.03;78.10] C 0/1,231   0/1,906 0 1,231
ref
S3379
R6254		 Clementi, 2010 Situs inversus /- dextrocardia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 10.18 [0.66;157.14] 1/80   24/18,051 25 80
ref
Total 2 studies 5.49 [0.58;51.80] 25 1,311
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 1.55[0.03; 78.10]01,23133%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Clementi, 2010Clementi, 2010 10.18[0.66; 157.14]258067%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical Total (2 studies) I2 = 0% 5.49[0.58; 51.80]251,3110.550.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.55[0.03; 78.10]-1,231 -NAYoshihara (control unexposed, sick), 2012 1 case control studiescase control studies 10.18[0.66; 157.08]2580 -NAClementi, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 10.18[0.66; 157.08]2580 -NAClementi, 2010 1 unexposed, sickunexposed, sick 1.55[0.03; 78.10]-1,231 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 1.55[0.03; 78.10]-1,231 -NAYoshihara (control unexposed, sick), 2012 1   - Yes  - Yes 10.18[0.66; 157.08]2580 -NAClementi, 2010 1 All studiesAll studies 5.49[0.58; 51.80]251,3110%NAYoshihara (control unexposed, sick), 2012 Clementi, 2010 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3353

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale10.18[0.66; 157.08]2580 -NAClementi, 2010 1 unexposed, sick controlsunexposed, sick controls 1.55[0.03; 78.10]-1,231 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.23[0.01; 4.73]21,231 -NAYoshihara (control exposed to PTU), 2012 10.510.01.0