Carbimazole, Thiamazole (Methimazole)

Aplasia cutis congenita

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3353
R5982		 Yoshihara (control exposed to PTU), 2012 Aplasia cutis congenita 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 17.15 [0.98;300.52] C
excluded (control group) 		7/1,231   0/1,399 7 1,231
ref
S3350
R5845		 Yoshihara (control unexposed, sick), 2012 Aplasia cutis congenita 1st trimester retrospective cohort unexposed, sick Adjustment: No 23.36 [1.33;409.42] C 7/1,231   0/1,906 7 1,231
ref
Total 1 studies 23.36 [1.33;409.42] 7 1,231
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 23.36[1.33; 409.42]71,2310%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 23.36[1.33; 409.42]71,231 -NAYoshihara (control unexposed, sick), 2012 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 23.36[1.33; 409.42]71,231 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 23.36[1.33; 409.42]71,231 -NAYoshihara (control unexposed, sick), 2012 1 All studiesAll studies 23.36[1.33; 409.42]71,231 -NAYoshihara (control unexposed, sick), 2012 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3353

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale23.36[1.33; 409.42]71,231 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale17.15[0.98; 300.52]71,231 -NAYoshihara (control exposed to PTU), 2012 10.510.01.0