Carbimazole, Thiamazole (Methimazole)

Down syndrom / Trisomy 21

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3353
R5983		 Yoshihara (control exposed to PTU), 2012 Trisomy 21 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.71 [0.28;10.23] C
excluded (control group) 		3/1,231   2/1,399 5 1,231
ref
S3350
R5846		 Yoshihara (control unexposed, sick), 2012 Trisomy 21 1st trimester retrospective cohort unexposed, sick Adjustment: No 2.33 [0.39;13.94] C 3/1,231   2/1,906 5 1,231
ref
Total 1 studies 2.33 [0.39;13.94] 5 1,231
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 2.33[0.39; 13.94]51,2310%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.33[0.39; 13.94]51,231 -NAYoshihara (control unexposed, sick), 2012 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.33[0.39; 13.94]51,231 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 2.33[0.39; 13.94]51,231 -NAYoshihara (control unexposed, sick), 2012 1 All studiesAll studies 2.33[0.39; 13.94]51,231 -NAYoshihara (control unexposed, sick), 2012 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3353

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.33[0.39; 13.94]51,231 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.71[0.28; 10.23]51,231 -NAYoshihara (control exposed to PTU), 2012 10.510.01.0