Carbimazole, Thiamazole (Methimazole)

Choanal atresia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3379
R6252		 Clementi, 2010 Choanal atresia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 36.96 [6.60;207.09] 4/80   54/18,051 58 80
ref
S3357
R6099		 Barbero, 2008 Choanal atresia 1st trimester case control unexposed, disease free Adjustment: No 17.75 [3.49;121.40] 10/12   51/232 61 12
ref
Total 2 studies 25.89 [7.52;89.13] 119 92
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Clementi, 2010Clementi, 2010 36.96[6.60; 207.09]588051%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical Barbero, 2008Barbero, 2008 17.75[3.49; 121.40]611249%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: criticalROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 25.89[7.52; 89.13]119920.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 25.89[7.52; 89.13]119920%NAClementi, 2010 Barbero, 2008 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 25.89[7.52; 89.13]119920%NAClementi, 2010 Barbero, 2008 2 Tags Adjustment   - No  - No 17.75[3.01; 104.69]6112 -NABarbero, 2008 1   - Yes  - Yes 36.96[6.60; 207.03]5880 -NAClementi, 2010 1 All studiesAll studies 25.89[7.52; 89.13]119920%NAClementi, 2010 Barbero, 2008 20.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale25.89[7.52; 89.13]119920%NAClementi, 2010 Barbero, 2008 20.510.01.0