Carbimazole, Thiamazole (Methimazole)

Polydactyly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8483
R27814		 Yoshihara (Controls exposed to PTU), 2021 Polydactyly 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 7.99 [0.32;201.71] C
excluded (control group) 		0/23   1/541 1 23
ref
S8482
R27792		 Yoshihara (Controls unexposed, sick), 2021 Polydactyly 1st trimester retrospective cohort unexposed, sick Adjustment: No 21.09 [0.41;1087.34] C 0/23   0/475 0 23
ref
Total 1 studies 21.09 [0.41;1087.34] 0 23
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (Controls unexposed, sick), 2021Yoshihara, 2021 1 21.09[0.41; 1087.34]0230%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 21.09[0.41; 1087.34]-23 -NAYoshihara (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 21.09[0.41; 1087.34]-23 -NAYoshihara (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 21.09[0.41; 1087.34]-23 -NAYoshihara (Controls unexposed, sick), 2021 1 All studiesAll studies 21.09[0.41; 1087.34]-23 -NAYoshihara (Controls unexposed, sick), 2021 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8483

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale21.09[0.41; 1087.34]-23 -NAYoshihara (Controls unexposed, sick), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 7.99[0.32; 201.71]123 -NAYoshihara (Controls exposed to PTU), 2021 10.510.01.0