Carbimazole, Thiamazole (Methimazole)

Goiter

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3421
R10978		 Hawken (control exposed to PTU), 2016 Fetal goitre 2nd trimester retrospective cohort exposed to other treatment, sick Adjustment: No 1.00 [0.15;6.53] C 2/11   4/22 6 11
ref
S3563
R7100		 Gianetti (control exposed to PTU), 2015 Neonatal goiter at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.14 [0.01;3.40] C
excluded (control group) 		0/124   1/52 1 124
ref
S3562
R7089		 Gianetti (control unexposed, sick), 2015 Neonatal goiter at least 1st trimester excluded retrospective cohort unexposed, sick Adjustment: No 1.64 [0.03;83.17] C
excluded (exposition period) 		0/124   0/203 0 124
ref
S3455
R6562		 Dwarakanath (control exposed to PTU), 1999 Goitre throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No 1.00 [0.02;58.44] C 0/7   0/7 0 7
ref
S3468
R6633		 Momotani (control exposed to PTU), 1997 Goiter throughout pregnancy prospective cohort exposed to other treatment, sick Adjustment: No 0.79 [0.02;40.78] C 0/43   0/34 0 43
ref
Total 3 studies 0.96 [0.20;4.60] 6 61
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hawken (control exposed to PTU), 2016Hawken, 2016 1 1.00[0.15; 6.53]61169%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: lowROB mesure: criticalROB reporting: unclear Dwarakanath (control exposed to PTU), 1999Dwarakanath, 1999 2 1.00[0.02; 58.44]0715%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: unclear Momotani (control exposed to PTU), 1997Momotani, 1997 3 0.79[0.02; 40.78]04316%ROB confusion: criticalROB selection: unclearROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 0.96[0.20; 4.60]6610.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control exposed to PTU; 2: control exposed to PTU; 3: control exposed to PTU;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.96[0.20; 4.60]6610%NAHawken (control exposed to PTU), 2016 Dwarakanath (control exposed to PTU), 1999 Momotani (control exposed to PTU), 1997 3 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.96[0.20; 4.60]6610%NAHawken (control exposed to PTU), 2016 Dwarakanath (control exposed to PTU), 1999 Momotani (control exposed to PTU), 1997 3 Tags Adjustment   - No  - No 0.96[0.20; 4.60]6610%NAHawken (control exposed to PTU), 2016 Dwarakanath (control exposed to PTU), 1999 Momotani (control exposed to PTU), 1997 3 All studiesAll studies 0.96[0.20; 4.60]6610%NAHawken (control exposed to PTU), 2016 Dwarakanath (control exposed to PTU), 1999 Momotani (control exposed to PTU), 1997 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3563

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.96[0.20; 4.60]6610%NAHawken (control exposed to PTU), 2016 Dwarakanath (control exposed to PTU), 1999 Momotani (control exposed to PTU), 1997 30.510.01.0