Carbimazole, Thiamazole (Methimazole)

Hyperthyroidism / Thyrotoxicosis (fetal/neonatal)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3421
R10980		 Hawken (control exposed to PTU), 2016 Neonatal hyperthyroidism 2nd trimester retrospective cohort exposed to other treatment, sick Adjustment: No 0.65 [0.02;17.40] C 0/11   1/22 1 11
ref
S3455
R6568		 Dwarakanath (control exposed to PTU), 1999 Clinical thyroid dysfunction (neonatal thyrotoxicosis) throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No 1.00 [0.02;58.44] C 0/7   0/7 0 7
ref
Total 2 studies 0.77 [0.06;9.94] 1 18
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Hawken (control exposed to PTU), 2016Hawken, 2016 1 0.65[0.02; 17.40]11161%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: lowROB mesure: criticalROB reporting: unclear Dwarakanath (control exposed to PTU), 1999Dwarakanath, 1999 2 1.00[0.02; 58.44]0739%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear Total (2 studies) I2 = 0% 0.77[0.06; 9.94]1180.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control exposed to PTU; 2: control exposed to PTU;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.77[0.06; 9.94]1180%NAHawken (control exposed to PTU), 2016 Dwarakanath (control exposed to PTU), 1999 2 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.77[0.06; 9.94]1180%NAHawken (control exposed to PTU), 2016 Dwarakanath (control exposed to PTU), 1999 2 Tags Adjustment   - No  - No 0.77[0.06; 9.94]1180%NAHawken (control exposed to PTU), 2016 Dwarakanath (control exposed to PTU), 1999 2 All studiesAll studies 0.77[0.06; 9.94]1180%NAHawken (control exposed to PTU), 2016 Dwarakanath (control exposed to PTU), 1999 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.77[0.06; 9.94]1180%NAHawken (control exposed to PTU), 2016 Dwarakanath (control exposed to PTU), 1999 20.510.01.0