Carbimazole, Thiamazole (Methimazole)

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3563
R7103		 Gianetti (control exposed to PTU), 2015 Perinatal death at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.14 [0.01;3.40] C
excluded (control group) 		0/124   1/52 1 124
ref
S3562
R7092		 Gianetti (control unexposed, sick), 2015 Perinatal death at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.64 [0.03;83.17] C 0/124   0/203 0 124
ref
S3353
R5970		 Yoshihara (control exposed to PTU), 2012 Perinatal loss 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.79 [0.25;2.49] C
excluded (control group) 		5/1,426   7/1,578 12 1,426
ref
S3350
R5831		 Yoshihara (control unexposed, sick), 2012 Perinatal loss 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.66 [0.23;1.90] C 5/1,426   11/2,065 16 1,426
ref
Total 2 studies 0.70 [0.25;1.94] 16 1,550
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 1.64[0.03; 83.17]01247%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: unclear Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 0.66[0.23; 1.90]161,42693%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.70[0.25; 1.94]161,5500.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.70[0.25; 1.94]161,5500%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.70[0.25; 1.94]161,5500%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 Tags Adjustment   - No  - No 0.70[0.25; 1.94]161,5500%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 All studiesAll studies 0.70[0.25; 1.94]161,5500%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3353, 3563

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.70[0.25; 1.94]161,5500%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.64[0.21; 1.95]131,5502%NAGianetti (control exposed to PTU), 2015 Yoshihara (control exposed to PTU), 2012 20.510.01.0