Carbimazole, Thiamazole (Methimazole)

Maternal liver disorder / failure during pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3376
R6585		 Lo (control exposed to PTU), 2015 Maternal hepatotoxicity during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No 2.35 [0.10;58.31] C 0/79   1/556 1 79
ref
S3386
R6581		 Korelitz (control exposed to PTU), 2013 Livers disorders in pregnancy (in mothers) 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.43 [0.02;10.45] C
excluded (control group) 		0/1,201   1/1,533 1 1,201
ref
S3384
R6582		 Korelitz (control unexposed, disease free), 2013 Livers disorders in pregnancy (in mothers) 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 0.52 [0.03;8.31] C
excluded (control group) 		0/1,201   642/801,375 642 1,201
ref
S3385
R6583		 Korelitz (control unexposed, sick), 2013 Livers disorders in pregnancy (in mothers) 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 0.21 [0.01;3.69] C
excluded (exposition period) 		0/1,201   9/4,902 9 1,201
ref
Total 1 studies 2.35 [0.10;58.31] 1 79
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lo (control exposed to PTU), 2015Lo, 2015 1 2.35[0.10; 58.31]1790%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control exposed to PTU;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.35[0.10; 58.31]179 -NALo (control exposed to PTU), 2015 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 2.35[0.10; 58.31]179 -NALo (control exposed to PTU), 2015 1 Tags Adjustment   - No  - No 2.35[0.10; 58.31]179 -NALo (control exposed to PTU), 2015 1 All studiesAll studies 2.35[0.10; 58.31]179 -NALo (control exposed to PTU), 2015 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3386, 3384

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.35[0.10; 58.31]179 -NALo (control exposed to PTU), 2015 10.510.01.0