Carbimazole, Thiamazole (Methimazole)

Severe congenital heart defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3386
R6300		 Korelitz (control exposed to PTU), 2013 Complex congenital heart disease 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.31 [0.02;5.26] C
excluded (control group) 		0/108   13/915 13 108
ref
S3384
R6284		 Korelitz (control unexposed, disease free), 2013 Complex congenital heart disease 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 0.77 [0.05;12.33] C
excluded (control group) 		0/108   3,832/634,858 3,832 108
ref
S3385
R6292		 Korelitz (control unexposed, sick), 2013 Complex congenital heart disease 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 0.56 [0.03;9.31] C
excluded (exposition period) 		0/108   26/3,236 26 108
ref
S3353
R5986		 Yoshihara (control exposed to PTU), 2012 Congenital cardiovascular deformity 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.14 [0.02;57.32] C
excluded (control group) 		0/1,231   0/1,399 0 1,231
ref
S3350
R5849		 Yoshihara (control unexposed, sick), 2012 Congenital cardiovascular deformity 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.22 [0.01;4.28] C 0/1,231   3/1,906 3 1,231
ref
S3379
R6255		 Clementi, 2010 Cardiac outflow tract defects (OTD) 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 1.17 [0.30;4.58] 4/80   732/18,051 736 80
ref
Total 2 studies 0.87 [0.25;3.03] 739 1,311
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 0.22[0.01; 4.28]31,23118%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Clementi, 2010Clementi, 2010 1.17[0.30; 4.58]7368082%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical Total (2 studies) I2 = 0% 0.87[0.25; 3.03]7391,3110.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.22[0.01; 4.28]31,231 -NAYoshihara (control unexposed, sick), 2012 1 case control studiescase control studies 1.17[0.30; 4.57]73680 -NAClementi, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.17[0.30; 4.57]73680 -NAClementi, 2010 1 unexposed, sickunexposed, sick 0.22[0.01; 4.28]31,231 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 0.22[0.01; 4.28]31,231 -NAYoshihara (control unexposed, sick), 2012 1   - Yes  - Yes 1.17[0.30; 4.57]73680 -NAClementi, 2010 1 All studiesAll studies 0.87[0.25; 3.03]7391,3110%NAYoshihara (control unexposed, sick), 2012 Clementi, 2010 20.15.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3353, 3386, 3384

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.17[0.30; 4.57]73680 -NAClementi, 2010 1 unexposed, sick controlsunexposed, sick controls Out of scale0.22[0.01; 4.28]31,231 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.14[0.02; 57.32]-1,231 -NAYoshihara (control exposed to PTU), 2012 10.510.01.0