Carbimazole, Thiamazole (Methimazole)

Language disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3426
R29469		 Azizi, 2002 Verbal IQ - Wechsler preschool and primary scale of Intelligence (WPPSI) - 3-11 yr of age throughout pregnancy retrospective cohort unexposed (general population or NOS) Adjustment: No extrapolated (cont. endpoint) Matched 0.79 [0.29;2.11] -/23   -/30 - 23
ref
Total 1 studies 0.79 [0.29;2.13] 0 23
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Azizi, 2002Azizi, 2002 0.79[0.29; 2.11]-230%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.79[0.29; 2.13]-23 -NAAzizi, 2002 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.79[0.29; 2.13]-23 -NAAzizi, 2002 1 Tags Adjustment   - No  - No 0.79[0.29; 2.13]-23 -NAAzizi, 2002 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 0.79[0.29; 2.13]-23 -NAAzizi, 2002 1 MatchedMatched 0.79[0.29; 2.13]-23 -NAAzizi, 2002 1 All studiesAll studies 0.79[0.29; 2.13]-23 -NAAzizi, 2002 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.79[0.29; 2.13]-23 -NAAzizi, 2002 10.510.01.0