Carbimazole, Thiamazole (Methimazole)

Eye defects

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3447
R6438
Andersen (control exposed to PTU), 2019 Eye (Q10-15) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 8.51 [0.49;149.15] C
excluded (control group)
7/1,574   0/889 7 1,574
ref
S3446
R6423
Andersen (control unexposed, disease free), 2019 Eye (Q10-15) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 2.08 [0.99;4.38] C 7/1,574   2,480/1,159,181 2,487 1,574
ref
S3337
R5702
Andersen 2017 (control exposed to PTU), 2017 Eye early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 6.82 [0.33;143.00] C
excluded (control group)
2/162   0/218 2 162
ref
S3335
R5667
Andersen 2017 (control unexposed, disease free), 2017 Eye early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 2.71 [0.67;10.93] C
excluded (control group)
2/162   3,134/682,343 3,136 162
ref
S3336
R5681
Andersen 2017 (control unexposed, sick), 2017 Eye early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 4.83 [0.88;26.60] C 2/162   4/1,551 6 162
ref
S3386
R6299
Korelitz (control exposed to PTU), 2013 Congenital anomalies of eye 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 8.54 [0.53;137.56] C
excluded (control group)
1/108   1/915 2 108
ref
S3384
R6283
Korelitz (control unexposed, disease free), 2013 Congenital anomalies of eye 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 3.84 [0.54;27.55] C
excluded (control group)
1/108   1,540/634,858 1,541 108
ref
S3385
R6291
Korelitz (control unexposed, sick), 2013 Congenital anomalies of eye 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 3.77 [0.47;30.42] C
excluded (exposition period)
1/108   8/3,236 9 108
ref
Total 2 studies 2.38 [1.21;4.71] 2,493 1,736
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen (control unexposed, disease free), 2019Andersen, 2019 1 2.08[0.99; 4.38]2,4871,57484%ROB confusion: seriousROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 2 4.83[0.88; 26.60]616216%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.38[1.21; 4.71]2,4931,7360.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.38[1.21; 4.71]2,4931,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.08[0.99; 4.38]2,4871,574 -NAAndersen (control unexposed, disease free), 2019 1 unexposed, sickunexposed, sick 4.83[0.88; 26.60]6162 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 2.38[1.21; 4.71]2,4931,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2 All studiesAll studies 2.38[1.21; 4.71]2,4931,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3386, 3384, 3337, 3335, 3447

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.21[1.15; 4.26]5,6231,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, disease free), 2017 2 unexposed, sick controlsunexposed, sick controls 4.83[0.88; 26.60]6162 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 7.67[0.95; 61.72]91,7360%NAAndersen (control exposed to PTU), 2019 Andersen 2017 (control exposed to PTU), 2017 20.510.01.0