Carbimazole, Thiamazole (Methimazole)

Congenital heart defects

id	Study   Auto Andersen (control exposed to PTU), 2019Andersen (control unexposed, disease free), 2019Seo (control exposed to PTU), 2018Seo (control unexposed, NOS), 2018Andersen 2017 (control exposed to PTU), 2017Andersen 2017 (control unexposed, disease free), 2017Andersen 2017 (control unexposed, sick), 2017	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3447 R6441	Andersen (control exposed to PTU), 2019	Circulatory system (Q20-28)	early pregnancy	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	1.39 [0.77;2.50] C excluded (control group)	39/1,574   16/889	55	1,574		ref
S3446 R6426	Andersen (control unexposed, disease free), 2019	Circulatory system (Q20-28)	early pregnancy	population based cohort retrospective	unexposed, disease free	Adjustment: No	1.91 [1.39;2.63] C	39/1,574   15,195/1,159,181	15,234	1,574		ref
S3364 R6130	Seo (control exposed to PTU), 2018	Circulatory system (Q20–Q28)	1st trimester	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No	1.60 [1.14;2.25] C excluded (control group)	41/1,120   230/9,930	271	1,120		ref
S3365 R6142	Seo (control unexposed, NOS), 2018	Circulatory system (Q20–Q28)	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes	1.60 [1.17;2.19]	41/1,120   62,086/2,872,109	62,127	1,120		ref
S3337 R5705	Andersen 2017 (control exposed to PTU), 2017	Circulatory systems	early pregnancy	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	2.76 [0.68;11.19] C excluded (control group)	6/162   3/218	9	162		ref
S3335 R5670	Andersen 2017 (control unexposed, disease free), 2017	Circulatory systems	early pregnancy	population based cohort retrospective	unexposed, disease free excluded	Adjustment: No	1.98 [0.88;4.48] C excluded (control group)	6/162   12,981/682,343	12,987	162		ref
S3336 R5684	Andersen 2017 (control unexposed, sick), 2017	Circulatory systems	early pregnancy	population based cohort retrospective	unexposed, sick	Adjustment: No	1.53 [0.64;3.68] C	6/162   38/1,551	44	162		ref
					Total	3 studies	1.73 [1.40;2.15]		77,405	2,856
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 3337, 3335, 3364, 3447