Carbimazole, Thiamazole (Methimazole)

Digestive system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3446
R6428
Andersen (control unexposed, disease free), 2019 Digestive system (Q39-45) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 3.65 [2.23;5.98] C 16/1,574   3,251/1,159,181 3,267 1,574
ref
S3364
R6133
Seo (control exposed to PTU), 2018 Other digestive system (Q38–Q45) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 2.04 [1.06;3.94] C
excluded (control group)
11/1,120   48/9,930 59 1,120
ref
S3365
R6145
Seo (control unexposed, NOS), 2018 Other digestive system (Q38–Q45) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 2.34 [1.29;4.23] 11/1,120   11,991/2,872,109 12,002 1,120
ref
S3337
R5707
Andersen 2017 (control exposed to PTU), 2017 Digestive system early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.27 [0.01;5.60] C
excluded (control group)
0/162   2/218 2 162
ref
S3335
R5672
Andersen 2017 (control unexposed, disease free), 2017 Digestive system early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 1.19 [0.07;19.17] C
excluded (control group)
0/162   1,765/682,343 1,765 162
ref
S3336
R5686
Andersen 2017 (control unexposed, sick), 2017 Digestive system early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 1.06 [0.06;19.85] C 0/162   4/1,551 4 162
ref
Total 3 studies 2.99 [2.05;4.36] 15,273 2,856
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen (control unexposed, disease free), 2019Andersen, 2019 1 3.65[2.23; 5.98]3,2671,57458%ROB confusion: seriousROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Seo (control unexposed, NOS), 2018Seo, 2018 2 2.34[1.29; 4.23]12,0021,12040%ROB confusion: criticalROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 3 1.06[0.06; 19.85]41622%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 2.99[2.05; 4.36]15,2732,8560.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, NOS; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.99[2.05; 4.36]15,2732,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.02[1.96; 4.65]15,2692,69422%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 2 unexposed, sickunexposed, sick 1.06[0.06; 19.85]4162 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 3.53[2.17; 5.74]3,2711,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2   - Yes  - Yes 2.34[1.29; 4.24]12,0021,120 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 2.99[2.05; 4.36]15,2732,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3337, 3335, 3364

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.99[2.05; 4.36]17,0342,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 3 unexposed, sick controlsunexposed, sick controls 1.06[0.06; 19.85]4162 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.30[0.25; 6.82]611,28239%NASeo (control exposed to PTU), 2018 Andersen 2017 (control exposed to PTU), 2017 20.510.01.0