Carbimazole, Thiamazole (Methimazole)

Digestive system anomalies

id	Study   Auto Andersen (control unexposed, disease free), 2019Seo (control exposed to PTU), 2018Seo (control unexposed, NOS), 2018Andersen 2017 (control exposed to PTU), 2017Andersen 2017 (control unexposed, disease free), 2017Andersen 2017 (control unexposed, sick), 2017	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3446 R6428	Andersen (control unexposed, disease free), 2019	Digestive system (Q39-45)	early pregnancy	population based cohort retrospective	unexposed, disease free	Adjustment: No	3.65 [2.23;5.98] C	16/1,574   3,251/1,159,181	3,267	1,574		ref
S3364 R6133	Seo (control exposed to PTU), 2018	Other digestive system (Q38–Q45)	1st trimester	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No	2.04 [1.06;3.94] C excluded (control group)	11/1,120   48/9,930	59	1,120		ref
S3365 R6145	Seo (control unexposed, NOS), 2018	Other digestive system (Q38–Q45)	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes	2.34 [1.29;4.23]	11/1,120   11,991/2,872,109	12,002	1,120		ref
S3337 R5707	Andersen 2017 (control exposed to PTU), 2017	Digestive system	early pregnancy	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	0.27 [0.01;5.60] C excluded (control group)	0/162   2/218	2	162		ref
S3335 R5672	Andersen 2017 (control unexposed, disease free), 2017	Digestive system	early pregnancy	population based cohort retrospective	unexposed, disease free excluded	Adjustment: No	1.19 [0.07;19.17] C excluded (control group)	0/162   1,765/682,343	1,765	162		ref
S3336 R5686	Andersen 2017 (control unexposed, sick), 2017	Digestive system	early pregnancy	population based cohort retrospective	unexposed, sick	Adjustment: No	1.06 [0.06;19.85] C	0/162   4/1,551	4	162		ref
					Total	3 studies	2.99 [2.05;4.36]		15,273	2,856
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 3337, 3335, 3364