Carbimazole, Thiamazole (Methimazole)

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3563
R7094		 Gianetti (control exposed to PTU), 2015 Miscarriage (NOS) and voluntary abortions at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.20 [0.41;3.51] C
excluded (control group) 		14/124   5/52 19 124
ref
S3562
R7083		 Gianetti (control unexposed, sick), 2015 Miscarriage (NOS) and voluntary abortions at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 2.03 [0.90;4.54] C 14/124   12/203 26 124
ref
S3455
R6565		 Dwarakanath (control exposed to PTU), 1999 Abortions, stillbirths throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No 1.00 [0.02;58.44] C 0/7   0/7 0 7
ref
Total 2 studies 1.97 [0.89;4.35] 26 131
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 2.03[0.90; 4.54]2612496%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: unclear Dwarakanath (control exposed to PTU), 1999Dwarakanath, 1999 2 1.00[0.02; 58.44]074%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: unclear Total (2 studies) I2 = 0% 1.97[0.89; 4.35]261310.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control exposed to PTU;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.97[0.89; 4.35]261310%NAGianetti (control unexposed, sick), 2015 Dwarakanath (control exposed to PTU), 1999 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.03[0.90; 4.54]26124 -NAGianetti (control unexposed, sick), 2015 1 exposed to other treatment, sickexposed to other treatment, sick 1.00[0.02; 58.44]-7 -NADwarakanath (control exposed to PTU), 1999 1 Tags Adjustment   - No  - No 1.97[0.89; 4.35]261310%NAGianetti (control unexposed, sick), 2015 Dwarakanath (control exposed to PTU), 1999 2 All studiesAll studies 1.97[0.89; 4.35]261310%NAGianetti (control unexposed, sick), 2015 Dwarakanath (control exposed to PTU), 1999 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3563

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.03[0.90; 4.54]26124 -NAGianetti (control unexposed, sick), 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.18[0.42; 3.35]191310%NAGianetti (control exposed to PTU), 2015 Dwarakanath (control exposed to PTU), 1999 20.510.01.0