Carbimazole, Thiamazole (Methimazole)

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3353
R5971		 Yoshihara (control exposed to PTU), 2012 Miscarriage 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.11 [0.89;1.40] C
excluded (control group) 		165/1,426   166/1,578 331 1,426
ref
S3350
R5832		 Yoshihara (control unexposed, sick), 2012 Miscarriage 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.72 [1.36;2.17] C 165/1,426   146/2,065 311 1,426
ref
S3396
R6342		 Di Gianantonio, 2001 Spontaneous abortion 1st trimester prospective cohort unexposed, disease free Adjustment: No 10.11 [4.03;25.35] C 14/228   7/1,089 21 228
ref
Total 2 studies 3.94 [0.70;22.25] 332 1,654
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 1.72[1.36; 2.17]3111,42653%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Di Gianantonio, 2001Di Gianantonio, 2001 10.11[4.03; 25.35]2122847%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 93% 3.94[0.70; 22.25]3321,6540.550.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.94[0.70; 22.25]3321,65493%NAYoshihara (control unexposed, sick), 2012 Di Gianantonio, 2001 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 10.11[4.03; 25.35]21228 -NADi Gianantonio, 2001 1 unexposed, sickunexposed, sick 1.72[1.36; 2.17]3111,426 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 3.94[0.70; 22.25]3321,65493%NAYoshihara (control unexposed, sick), 2012 Di Gianantonio, 2001 2 All studiesAll studies 3.94[0.70; 22.25]3321,65493%NAYoshihara (control unexposed, sick), 2012 Di Gianantonio, 2001 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3353

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale10.11[4.03; 25.35]21228 -NADi Gianantonio, 2001 1 unexposed, sick controlsunexposed, sick controls 1.72[1.36; 2.17]3111,426 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.11[0.89; 1.40]3311,426 -NAYoshihara (control exposed to PTU), 2012 10.510.01.0