Carbimazole, Thiamazole (Methimazole)

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3563
R7093		 Gianetti (control exposed to PTU), 2015 Voluntary abortions at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.84 [0.07;9.43] C
excluded (control group) 		2/124   1/52 3 124
ref
S3562
R7082		 Gianetti (control unexposed, sick), 2015 Voluntary abortions at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 3.31 [0.30;36.91] C 2/124   1/203 3 124
ref
S3353
R5972		 Yoshihara (control exposed to PTU), 2012 Abortion 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 2.59 [1.34;4.98] C
excluded (control group) 		30/1,426   13/1,578 43 1,426
ref
S3350
R5833		 Yoshihara (control unexposed, sick), 2012 Abortion 1st trimester retrospective cohort unexposed, sick Adjustment: No 3.39 [1.76;6.53] C 30/1,426   13/2,065 43 1,426
ref
Total 2 studies 3.39 [1.80;6.37] 46 1,550
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 3.31[0.30; 36.91]31247%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: unclear Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 3.39[1.76; 6.53]431,42693%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 3.39[1.80; 6.37]461,5500.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.39[1.80; 6.37]461,5500%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.39[1.80; 6.37]461,5500%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 Tags Adjustment   - No  - No 3.39[1.80; 6.37]461,5500%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 All studiesAll studies 3.39[1.80; 6.37]461,5500%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3353, 3563

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 3.39[1.80; 6.37]461,5500%NAGianetti (control unexposed, sick), 2015 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.40[1.27; 4.51]461,5500%NAGianetti (control exposed to PTU), 2015 Yoshihara (control exposed to PTU), 2012 20.510.01.0