Carbimazole, Thiamazole (Methimazole)

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3563
R7095		 Gianetti (control exposed to PTU), 2015 Preterm at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.26 [0.13;12.45] C
excluded (control group) 		3/124   1/52 4 124
ref
S3562
R7084		 Gianetti (control unexposed, sick), 2015 Preterm at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.48 [0.13;1.77] C 3/124   10/203 13 124
ref
S3345
R5815		 Chen (control exposed to PTU), 2011 Preterm birth, birth >24 and <37 weeks of gestation during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.83 [0.85;3.91] C
excluded (control group) 		9/73   45/630 54 73
ref
S3343
R5807		 Chen (control unexposed, disease free), 2011 Preterm birth, birth >24 and <37 weeks of gestation during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.99 [0.99;4.01] C
excluded (control group) 		9/73   934/14,150 943 73
ref
S3344
R5811		 Chen (control unexposed, sick), 2011 Preterm birth, birth >24 and <37 weeks of gestation during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 1.60 [0.78;3.29] 9/73   162/2,127 171 73
ref
S3426
R8715		 Azizi, 2002 Preterm throughout pregnancy retrospective cohort unexposed (general population or NOS) Adjustment: No Matched 1.31 [0.03;68.65] C 0/23   0/30 0 23
ref
S3455
R6564		 Dwarakanath (control exposed to PTU), 1999 Preterm labour throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No 1.00 [0.02;58.44] C 0/7   0/7 0 7
ref
Total 4 studies 1.21 [0.65;2.23] 184 227
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 0.48[0.13; 1.77]1312422%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear Chen (control unexposed, sick), 2011Chen, 2011 2 1.60[0.78; 3.29]1717373%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Azizi, 2002Azizi, 2002 1.31[0.03; 68.65]0232%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: lowROB mesure: moderateROB reporting: moderate Dwarakanath (control exposed to PTU), 1999Dwarakanath, 1999 3 1.00[0.02; 58.44]072%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear Total (4 studies) I2 = 0% 1.21[0.65; 2.23]1842270.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick; 3: control exposed to PTU;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.21[0.65; 2.23]1842270%NAGianetti (control unexposed, sick), 2015 Chen (control unexposed, sick), 2011 Azizi, 2002 Dwarakanath (control exposed to PTU), 1999 4 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.31[0.03; 68.65]-23 -NAAzizi, 2002 1 unexposed, sickunexposed, sick 1.00[0.31; 3.16]18419760%NAGianetti (control unexposed, sick), 2015 Chen (control unexposed, sick), 2011 2 exposed to other treatment, sickexposed to other treatment, sick 1.00[0.02; 58.44]-7 -NADwarakanath (control exposed to PTU), 1999 1 Tags Adjustment   - No  - No 0.56[0.17; 1.83]131540%NAGianetti (control unexposed, sick), 2015 Azizi, 2002 Dwarakanath (control exposed to PTU), 1999 3   - Yes  - Yes 1.60[0.78; 3.29]17173 -NAChen (control unexposed, sick), 2011 1 MatchedMatched 1.31[0.03; 68.65]-23 -NAAzizi, 2002 1 All studiesAll studies 1.21[0.65; 2.23]1842270%NAGianetti (control unexposed, sick), 2015 Chen (control unexposed, sick), 2011 Azizi, 2002 Dwarakanath (control exposed to PTU), 1999 40.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-4.95.12.4910.000Gianetti (control unexposed, sick), 2015Chen (control unexposed, sick), 2011Azizi, 2002Dwarakanath (control exposed to PTU), 1999

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 3345, 3343, 3563

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.96[0.99; 3.92]943960%NAChen (control unexposed, disease free), 2011 Azizi, 2002 2 unexposed, sick controlsunexposed, sick controls 1.00[0.31; 3.16]18419760%NAGianetti (control unexposed, sick), 2015 Chen (control unexposed, sick), 2011 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.73[0.85; 3.53]582040%NAGianetti (control exposed to PTU), 2015 Chen (control exposed to PTU), 2011 Dwarakanath (control exposed to PTU), 1999 30.510.01.0