Carbimazole, Thiamazole (Methimazole)

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3345
R5814		 Chen (control exposed to PTU), 2011 Low birth weight < 2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.53 [0.72;3.25] C
excluded (control group) 		9/73   53/630 62 73
ref
S3343
R5806		 Chen (control unexposed, disease free), 2011 Low birth weight < 2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 2.60 [1.29;5.25] C
excluded (control group) 		9/73   725/14,150 734 73
ref
S3344
R5810		 Chen (control unexposed, sick), 2011 Low birth weight < 2500 g during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 2.15 [0.98;4.45] 9/73   129/2,127 138 73
ref
S3455
R6563		 Dwarakanath (control exposed to PTU), 1999 Low birth weight throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No 0.42 [0.03;6.06] C 1/7   2/7 3 7
ref
Total 2 studies 1.60 [0.46;5.51] 141 80
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chen (control unexposed, sick), 2011Chen, 2011 1 2.15[0.98; 4.45]1387382%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Dwarakanath (control exposed to PTU), 1999Dwarakanath, 1999 2 0.42[0.03; 6.06]3718%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear Total (2 studies) I2 = 25% 1.60[0.46; 5.51]141800.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control exposed to PTU;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.60[0.46; 5.51]1418025%NAChen (control unexposed, sick), 2011 Dwarakanath (control exposed to PTU), 1999 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.15[1.01; 4.58]13873 -NAChen (control unexposed, sick), 2011 1 exposed to other treatment, sickexposed to other treatment, sick 0.42[0.03; 6.06]37 -NADwarakanath (control exposed to PTU), 1999 1 Tags Adjustment   - No  - No 0.42[0.03; 6.06]37 -NADwarakanath (control exposed to PTU), 1999 1   - Yes  - Yes 2.15[1.01; 4.58]13873 -NAChen (control unexposed, sick), 2011 1 All studiesAll studies 1.60[0.46; 5.51]1418025%NAChen (control unexposed, sick), 2011 Dwarakanath (control exposed to PTU), 1999 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3345, 3343

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.60[1.29; 5.25]73473 -NAChen (control unexposed, disease free), 2011 1 unexposed, sick controlsunexposed, sick controls 2.15[1.01; 4.58]13873 -NAChen (control unexposed, sick), 2011 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.39[0.67; 2.87]65800%NAChen (control exposed to PTU), 2011 Dwarakanath (control exposed to PTU), 1999 20.510.01.0