Carbimazole, Thiamazole (Methimazole)

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3345
R5816		 Chen (control exposed to PTU), 2011 Small for gestational age, birthweight < 10th percentile of the population-wide distribution of gestational age-specific birthweight in Taiwan during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.18 [0.65;2.16] C
excluded (control group) 		15/73   113/630 128 73
ref
S3343
R5808		 Chen (control unexposed, disease free), 2011 Small for gestational age, birthweight < 10th percentile of the population-wide distribution of gestational age-specific birthweight in Taiwan during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.45 [0.82;2.56] C
excluded (control group) 		15/73   2,146/14,150 2,161 73
ref
S3344
R5812		 Chen (control unexposed, sick), 2011 Small for gestational age, birthweight < 10th percentile of the population-wide distribution of gestational age-specific birthweight in Taiwan during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 1.25 [0.70;2.24] 15/73   366/2,127 381 73
ref
Total 1 studies 1.25 [0.70;2.24] 381 73
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chen (control unexposed, sick), 2011Chen, 2011 1 1.25[0.70; 2.24]381730%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.25[0.70; 2.24]38173 -NAChen (control unexposed, sick), 2011 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.25[0.70; 2.24]38173 -NAChen (control unexposed, sick), 2011 1 Tags Adjustment   - Yes  - Yes 1.25[0.70; 2.24]38173 -NAChen (control unexposed, sick), 2011 1 All studiesAll studies 1.25[0.70; 2.24]38173 -NAChen (control unexposed, sick), 2011 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3345, 3343

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.45[0.82; 2.56]2,16173 -NAChen (control unexposed, disease free), 2011 1 unexposed, sick controlsunexposed, sick controls 1.25[0.70; 2.24]38173 -NAChen (control unexposed, sick), 2011 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.18[0.65; 2.16]12873 -NAChen (control exposed to PTU), 2011 10.510.01.0