Thiouracil, propylthiouracil, benzylthiouracil

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3564
R7108		 Gianetti (control exposed to MMI), 2015 Preeclampsia at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 2.40 [0.05;122.50] C
excluded (control group) 		0/52   0/124 0 52
ref
S3565
R7119		 Gianetti (control unexposed, sick), 2015 Preeclampsia throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 1.30 [0.05;32.49] C 0/52   1/203 1 52
ref
S3439
R6384		 Davis, 1989 Preeclampsia during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 0.32 [0.05;2.02] C 5/52   2/8 7 52
ref
Total 2 studies 0.45 [0.09;2.24] 8 104
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gianetti (control unexposed, sick), 2015Gianetti, 2015 1 1.30[0.05; 32.49]15225%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: critical Davis, 1989Davis, 1989 0.32[0.05; 2.02]75275%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear Total (2 studies) I2 = 0% 0.45[0.09; 2.24]81040.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.45[0.09; 2.24]81040%NAGianetti (control unexposed, sick), 2015 Davis, 1989 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.45[0.09; 2.24]81040%NAGianetti (control unexposed, sick), 2015 Davis, 1989 2 Tags Adjustment   - No  - No 0.45[0.09; 2.24]81040%NAGianetti (control unexposed, sick), 2015 Davis, 1989 2 All studiesAll studies 0.45[0.09; 2.24]81040%NAGianetti (control unexposed, sick), 2015 Davis, 1989 20.15.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3564

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.45[0.09; 2.24]81040%NAGianetti (control unexposed, sick), 2015 Davis, 1989 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.40[0.05; 122.50]-52 -NAGianetti (control exposed to MMI), 2015 10.510.01.0