Thiouracil, propylthiouracil, benzylthiouracil

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3355
R6063		 Yoshihara (control exposed to MMI), 2012 Cheiloschisis, palatoschisis 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 2.64 [0.11;64.91] C
excluded (control group) 		1/1,399   0/1,231 1 1,399
ref
S3354
R6020		 Yoshihara (control unexposed, sick), 2012 Cheiloschisis, palatoschisis 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.68 [0.06;7.52] C 1/1,399   2/1,906 3 1,399
ref
Total 1 studies 0.68 [0.06;7.52] 3 1,399
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 0.68[0.06; 7.52]31,3990%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.68[0.06; 7.52]31,399 -NAYoshihara (control unexposed, sick), 2012 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.68[0.06; 7.52]31,399 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 0.68[0.06; 7.52]31,399 -NAYoshihara (control unexposed, sick), 2012 1 All studiesAll studies 0.68[0.06; 7.52]31,399 -NAYoshihara (control unexposed, sick), 2012 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.68[0.06; 7.52]31,399 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.64[0.11; 64.91]11,399 -NAYoshihara (control exposed to MMI), 2012 10.510.01.0