Thiouracil, propylthiouracil, benzylthiouracil

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8484
R27830		 Yoshihara (Controls exposed to MMI), 2021 Ventricular septal defect 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.38 [0.02;7.23] C
excluded (control group) 		4/541   0/23 4 541
ref
S8481
R27764		 Yoshihara (Controls unexposed, sick), 2021 Ventricular septal defect 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.70 [0.19;2.62] C 4/541   5/475 9 541
ref
S3355
R6060		 Yoshihara (control exposed to MMI), 2012 Ventricular septal defect 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.78 [0.30;2.03] C
excluded (control group) 		8/1,399   9/1,231 17 1,399
ref
S3354
R6017		 Yoshihara (control unexposed, sick), 2012 Ventricular septal defect 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.99 [0.40;2.47] C 8/1,399   11/1,906 19 1,399
ref
Total 2 studies 0.89 [0.42;1.88] 28 1,940
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (Controls unexposed, sick), 2021Yoshihara, 2021 1 0.70[0.19; 2.62]954132%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 0.99[0.40; 2.47]191,39968%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.89[0.42; 1.88]281,9400.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.89[0.42; 1.88]281,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.89[0.42; 1.88]281,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 Tags Adjustment   - No  - No 0.89[0.42; 1.88]281,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 All studiesAll studies 0.89[0.42; 1.88]281,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355, 8484

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.89[0.42; 1.88]281,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.73[0.29; 1.81]211,9400%NAYoshihara (Controls exposed to MMI), 2021 Yoshihara (control exposed to MMI), 2012 20.510.01.0