Thiouracil, propylthiouracil, benzylthiouracil

Atrial septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3355
R6061		 Yoshihara (control exposed to MMI), 2012 Atrial septal defect 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 4.41 [0.21;91.86] C
excluded (control group) 		2/1,399   0/1,231 2 1,399
ref
S3354
R6018		 Yoshihara (control unexposed, sick), 2012 Atrial septal defect 1st trimester retrospective cohort unexposed, sick Adjustment: No 2.73 [0.25;30.11] C 2/1,399   1/1,906 3 1,399
ref
Total 1 studies 2.73 [0.25;30.11] 3 1,399
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 2.73[0.25; 30.11]31,3990%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.73[0.25; 30.11]31,399 -NAYoshihara (control unexposed, sick), 2012 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.73[0.25; 30.11]31,399 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 2.73[0.25; 30.11]31,399 -NAYoshihara (control unexposed, sick), 2012 1 All studiesAll studies 2.73[0.25; 30.11]31,399 -NAYoshihara (control unexposed, sick), 2012 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.73[0.25; 30.11]31,399 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.41[0.21; 91.86]21,399 -NAYoshihara (control exposed to MMI), 2012 10.510.01.0