Thiouracil, propylthiouracil, benzylthiouracil

Hypospadias

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8484
R27837		 Yoshihara (Controls exposed to MMI), 2021 Hypospadias 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.21 [0.01;4.48] C
excluded (control group) 		2/541   0/23 2 541
ref
S8481
R27771		 Yoshihara (Controls unexposed, sick), 2021 Hypospadias 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.76 [0.16;19.46] C 2/541   1/475 3 541
ref
S3355
R6097		 Yoshihara (control exposed to MMI), 2012 Hypospadias 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 2.64 [0.11;64.91] C
excluded (control group) 		1/1,399   0/1,231 1 1,399
ref
S3354
R6054		 Yoshihara (control unexposed, sick), 2012 Hypospadias 1st trimester retrospective cohort unexposed, sick Adjustment: No 4.09 [0.17;100.49] C 1/1,399   0/1,906 1 1,399
ref
Total 2 studies 2.38 [0.35;16.30] 4 1,940
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (Controls unexposed, sick), 2021Yoshihara, 2021 1 1.76[0.16; 19.46]354164%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 4.09[0.17; 100.49]11,39936%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 2.38[0.35; 16.30]41,9400.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.38[0.35; 16.30]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.38[0.35; 16.30]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 Tags Adjustment   - No  - No 2.38[0.35; 16.30]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 All studiesAll studies 2.38[0.35; 16.30]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355, 8484

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.38[0.35; 16.30]41,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.71[0.06; 8.53]31,94021%NAYoshihara (Controls exposed to MMI), 2021 Yoshihara (control exposed to MMI), 2012 20.510.01.0