Thiouracil, propylthiouracil, benzylthiouracil

Ear malformations

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3340
R5754
Andersen 2017 (control exposed to MMI/CMZ), 2017 Ear early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 3.75 [0.18;78.59] C
excluded (control group)
2/218   0/162 2 218
ref
S3339
R5737
Andersen 2017 (control unexposed, disease free), 2017 Ear early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 5.41 [1.34;21.79] C
excluded (control group)
2/218   1,166/682,343 1,168 218
ref
S3338
R5720
Andersen 2017 (control unexposed, sick), 2017 Ear early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 35.97 [1.72;751.88] C 2/218   0/1,551 2 218
ref
Total 1 studies 35.97 [1.72;751.88] 2 218
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 1 35.97[1.72; 751.88]22180%ROB confusion: criticalROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate0.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 35.97[1.72; 751.88]2218 -NAAndersen 2017 (control unexposed, sick), 2017 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 35.97[1.72; 751.88]2218 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 35.97[1.72; 751.88]2218 -NAAndersen 2017 (control unexposed, sick), 2017 1 All studiesAll studies 35.97[1.72; 751.88]2218 -NAAndersen 2017 (control unexposed, sick), 2017 10.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3340, 3339

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.41[1.34; 21.79]1,168218 -NAAndersen 2017 (control unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls Out of scale35.97[1.72; 751.88]2218 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.75[0.18; 78.59]2218 -NAAndersen 2017 (control exposed to MMI/CMZ), 2017 10.510.01.0