Thiouracil, propylthiouracil, benzylthiouracil

Other congenital malformations (Q80-84)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3340
R5762		 Andersen 2017 (control exposed to MMI/CMZ), 2017 Integumentary system including breast malformations (Q80–84) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.74 [0.01;37.62] C
excluded (control group) 		0/218   0/162 0 218
ref
S3339
R5745		 Andersen 2017 (control unexposed, disease free), 2017 Integumentary system including breast malformations (Q80–84) early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 0.55 [0.03;8.87] C
excluded (control group) 		0/218   2,826/682,343 2,826 218
ref
S3338
R5728		 Andersen 2017 (control unexposed, sick), 2017 Integumentary system including breast malformations (Q80–84) early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 0.37 [0.02;6.43] C 0/218   9/1,551 9 218
ref
Total 1 studies 0.37 [0.02;6.43] 9 218
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 1 0.37[0.02; 6.43]92180%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.37[0.02; 6.43]9218 -NAAndersen 2017 (control unexposed, sick), 2017 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.37[0.02; 6.43]9218 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 0.37[0.02; 6.43]9218 -NAAndersen 2017 (control unexposed, sick), 2017 1 All studiesAll studies 0.37[0.02; 6.43]9218 -NAAndersen 2017 (control unexposed, sick), 2017 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3340, 3339

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.55[0.03; 8.87]2,826218 -NAAndersen 2017 (control unexposed, disease free), 2017 1 unexposed, sick controlsunexposed, sick controls Out of scale0.37[0.02; 6.43]9218 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.74[0.01; 37.62]-218 -NAAndersen 2017 (control exposed to MMI/CMZ), 2017 10.510.01.0