Thiouracil, propylthiouracil, benzylthiouracil

Syndromes and chromosomal abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3448
R6464		 Andersen 2019 (control exposed to MMI/CMZ), 2019 Other malformations (Q85-99) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.79 [0.24;2.56] C
excluded (control group) 		4/889   9/1,574 13 889
ref
S3449
R6479		 Andersen 2019 (control unexposed, disease free), 2019 Other malformations (Q85-99) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 0.94 [0.35;2.52] C 4/889   5,532/1,159,181 5,536 889
ref
S3340
R5763		 Andersen 2017 (control exposed to MMI/CMZ), 2017 Other malformations (Q85-99) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.25 [0.01;6.08] C
excluded (control group) 		0/218   1/162 1 218
ref
S3339
R5746		 Andersen 2017 (control unexposed, disease free), 2017 Other malformations (Q85-99) early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 0.64 [0.04;10.26] C
excluded (control group) 		0/218   2,443/682,343 2,443 218
ref
S3338
R5729		 Andersen 2017 (control unexposed, sick), 2017 Other malformations (Q85-99) early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 0.31 [0.02;5.24] C 0/218   11/1,551 11 218
ref
Total 2 studies 0.84 [0.33;2.12] 5,547 1,107
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen 2019 (control unexposed, disease free), 2019Andersen 2019, 2019 1 0.94[0.35; 2.52]5,53688989%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 2 0.31[0.02; 5.24]1121811%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.84[0.33; 2.12]5,5471,1070.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.84[0.33; 2.12]5,5471,1070%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.94[0.35; 2.52]5,536889 -NAAndersen 2019 (control unexposed, disease free), 2019 1 unexposed, sickunexposed, sick 0.31[0.02; 5.24]11218 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 0.84[0.33; 2.12]5,5471,1070%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2 All studiesAll studies 0.84[0.33; 2.12]5,5471,1070%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3340, 3339, 3448

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.90[0.36; 2.28]7,9791,1070%NAAndersen 2019 (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, disease free), 2017 2 unexposed, sick controlsunexposed, sick controls Out of scale0.31[0.02; 5.24]11218 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.68[0.23; 2.07]141,1070%NAAndersen 2019 (control exposed to MMI/CMZ), 2019 Andersen 2017 (control exposed to MMI/CMZ), 2017 20.510.01.0