Thiouracil, propylthiouracil, benzylthiouracil

Carbimazole embryopathy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3366
R6162		 Seo (control exposed to MMI), 2018 MMI embryopathy (at least 1 of the following diagnoses: choanal atresia, esophageal atresia, omphalocele, omphalomesenteric duct anomaly, or aplasia cutis) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.17 [0.07;0.41] C
excluded (control group) 		12/9,930   8/1,120 20 9,930
ref
S3367
R6174		 Seo (control unexposed, NOS), 2018 MMI embryopathy (at least 1 of the following diagnoses: choanal atresia, esophageal atresia, omphalocele, omphalomesenteric duct anomaly, or aplasia cutis) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.65 [0.93;2.91] 12/9,930   2,019/2,872,109 2,031 9,930
ref
S3355
R8738		 Yoshihara (control exposed to MMI), 2012 MMI/CMZ embryopathy (at least 1 of following malfo: choanal atresia, esophageal atresia, omphalocele or aplasia cutis) 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.03 [0.00;0.50] C
excluded (control group) 		0/1,399   14/1,231 14 1,399
ref
S3354
R8739		 Yoshihara (control unexposed, sick), 2012 MMI/CMZ embryopathy (at least 1 of following malfo: choanal atresia, esophageal atresia, omphalocele or aplasia cutis) 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.36 [0.03;68.71] C 0/1,399   0/1,906 0 1,399
ref
S3380
R8737		 Clementi, 2010 Choanal atresia or omphalocele (as a part of Carbimazole embryopathy) 1st trimester case control unexposed (general population or NOS) Adjustment: No 0.90 [0.06;14.53] C 0/94   212/36,168 212 94
ref
Total 3 studies 1.60 [0.92;2.79] 2,243 11,423
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Seo (control unexposed, NOS), 2018Seo, 2018 1 1.65[0.93; 2.91]2,0319,93094%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 1.36[0.03; 68.71]01,3992%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Clementi, 2010Clementi, 2010 0.90[0.06; 14.53]212944%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical Total (3 studies) I2 = 0% 1.60[0.92; 2.79]2,24311,4230.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, NOS; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.64[0.93; 2.89]2,03111,3290%NASeo (control unexposed, NOS), 2018 Yoshihara (control unexposed, sick), 2012 2 case control studiescase control studies 0.90[0.06; 14.53]21294 -NAClementi, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.61[0.92; 2.82]2,24310,0240%NASeo (control unexposed, NOS), 2018 Clementi, 2010 2 unexposed, sickunexposed, sick 1.36[0.03; 68.71]-1,399 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 1.03[0.11; 10.00]2121,4930%NAYoshihara (control unexposed, sick), 2012 Clementi, 2010 2   - Yes  - Yes 1.65[0.93; 2.92]2,0319,930 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.60[0.92; 2.79]2,24311,4230%NASeo (control unexposed, NOS), 2018 Yoshihara (control unexposed, sick), 2012 Clementi, 2010 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355, 3366

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.61[0.92; 2.82]2,24310,0240%NASeo (control unexposed, NOS), 2018 Clementi, 2010 2 unexposed, sick controlsunexposed, sick controls 1.36[0.03; 68.71]-1,399 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.12[0.03; 0.45]3411,32923%NASeo (control exposed to MMI), 2018 Yoshihara (control exposed to MMI), 2012 20.510.01.0