Thiouracil, propylthiouracil, benzylthiouracil

Situs inversus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3355
R6065		 Yoshihara (control exposed to MMI), 2012 Situs inversus (complete and viscerum) 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 4.41 [0.21;91.86] C
excluded (control group) 		2/1,399   0/1,231 2 1,399
ref
S3354
R6022		 Yoshihara (control unexposed, sick), 2012 Situs inversus (complete and viscerum) 1st trimester retrospective cohort unexposed, sick Adjustment: No 6.82 [0.33;142.23] C 2/1,399   0/1,906 2 1,399
ref
S3380
R6259		 Clementi, 2010 Situs inversus /- dextrocardia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 32.16 [1.64;630.66] 3/47   22/18,084 25 47
ref
Total 2 studies 15.05 [1.80;126.08] 27 1,446
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 6.82[0.33; 142.23]21,39949%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Clementi, 2010Clementi, 2010 32.16[1.64; 630.66]254751%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical Total (2 studies) I2 = 0% 15.05[1.80; 126.08]271,4460.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 6.82[0.33; 142.23]21,399 -NAYoshihara (control unexposed, sick), 2012 1 case control studiescase control studies 32.16[1.64; 630.65]2547 -NAClementi, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 32.16[1.64; 630.65]2547 -NAClementi, 2010 1 unexposed, sickunexposed, sick 6.82[0.33; 142.23]21,399 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 6.82[0.33; 142.23]21,399 -NAYoshihara (control unexposed, sick), 2012 1   - Yes  - Yes 32.16[1.64; 630.65]2547 -NAClementi, 2010 1 All studiesAll studies 15.05[1.80; 126.08]271,4460%NAYoshihara (control unexposed, sick), 2012 Clementi, 2010 20.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale32.16[1.64; 630.65]2547 -NAClementi, 2010 1 unexposed, sick controlsunexposed, sick controls 6.82[0.33; 142.23]21,399 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.41[0.21; 91.86]21,399 -NAYoshihara (control exposed to MMI), 2012 10.510.01.0