Thiouracil, propylthiouracil, benzylthiouracil

Omphalocele

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8484
R27833		 Yoshihara (Controls exposed to MMI), 2021 Omphalocele 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.21 [0.01;4.48] C
excluded (control group) 		2/541   0/23 2 541
ref
S8481
R27767		 Yoshihara (Controls unexposed, sick), 2021 Omphalocele 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.58 [0.10;3.51] C 2/541   3/475 5 541
ref
S3355
R6066		 Yoshihara (control exposed to MMI), 2012 Omphalocele 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.07 [0.00;1.20] C
excluded (control group) 		0/1,399   6/1,231 6 1,399
ref
S3354
R6023		 Yoshihara (control unexposed, sick), 2012 Omphalocele 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.36 [0.03;68.71] C 0/1,399   0/1,906 0 1,399
ref
S3380
R6258		 Clementi, 2010 Omphalocele 1st trimester case control unexposed (general population or NOS) Adjustment: No 1.23 [0.08;20.04] C 0/47   154/18,084 154 47
ref
Total 3 studies 0.79 [0.19;3.22] 159 1,987
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (Controls unexposed, sick), 2021Yoshihara, 2021 1 0.58[0.10; 3.51]554162%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: moderate Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 2 1.36[0.03; 68.71]01,39913%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Clementi, 2010Clementi, 2010 1.23[0.08; 20.04]1544725%ROB confusion: criticalROB selection: criticalROB classification: unclearROB missing: unclearROB mesure: criticalROB reporting: critical Total (3 studies) I2 = 0% 0.79[0.19; 3.22]1591,9870.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.68[0.13; 3.45]51,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 case control studiescase control studies 1.23[0.08; 20.04]15447 -NAClementi, 2010 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.23[0.08; 20.04]15447 -NAClementi, 2010 1 unexposed, sickunexposed, sick 0.68[0.13; 3.45]51,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 Tags Adjustment   - No  - No 0.79[0.19; 3.22]1591,9870%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 Clementi, 2010 3 All studiesAll studies 0.79[0.19; 3.22]1591,9870%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 Clementi, 2010 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355, 8484

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.23[0.08; 20.04]15447 -NAClementi, 2010 1 unexposed, sick controlsunexposed, sick controls 0.68[0.13; 3.45]51,9400%NAYoshihara (Controls unexposed, sick), 2021 Yoshihara (control unexposed, sick), 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.11[0.01; 0.93]81,9400%NAYoshihara (Controls exposed to MMI), 2021 Yoshihara (control exposed to MMI), 2012 20.510.01.0