Thiouracil, propylthiouracil, benzylthiouracil

Down syndrom / Trisomy 21

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3355
R6069		 Yoshihara (control exposed to MMI), 2012 Trisomy 21 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.59 [0.10;3.51] C
excluded (control group) 		2/1,399   3/1,231 5 1,399
ref
S3354
R6026		 Yoshihara (control unexposed, sick), 2012 Trisomy 21 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.36 [0.19;9.69] C 2/1,399   2/1,906 4 1,399
ref
Total 1 studies 1.36 [0.19;9.69] 4 1,399
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 1.36[0.19; 9.69]41,3990%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.36[0.19; 9.69]41,399 -NAYoshihara (control unexposed, sick), 2012 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.36[0.19; 9.69]41,399 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 1.36[0.19; 9.69]41,399 -NAYoshihara (control unexposed, sick), 2012 1 All studiesAll studies 1.36[0.19; 9.69]41,399 -NAYoshihara (control unexposed, sick), 2012 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.36[0.19; 9.69]41,399 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.59[0.10; 3.51]51,399 -NAYoshihara (control exposed to MMI), 2012 10.510.01.0