Thiouracil, propylthiouracil, benzylthiouracil

Craniosynostosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3359
R6107		 Howley, 2017 Craniosynostosis 1st trimester case control unexposed, disease free Adjustment: No 1.47 [0.32;6.73] C 2/12   1,532/12,822 1,534 12
ref
S3355
R6077		 Yoshihara (control exposed to MMI), 2012 Craniosynostosis 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.29 [0.01;7.20] C
excluded (control group) 		0/1,399   1/1,231 1 1,399
ref
S3354
R6034		 Yoshihara (control unexposed, sick), 2012 Craniosynostosis 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.45 [0.02;11.15] C 0/1,399   1/1,906 1 1,399
ref
Total 2 studies 1.19 [0.30;4.68] 1,535 1,411
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Howley, 2017Howley, 2017 1.47[0.32; 6.73]1,5341282%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Yoshihara (control unexposed, sick), 2012Yoshihara, 2012 1 0.45[0.02; 11.15]11,39918%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.19[0.30; 4.68]1,5351,4110.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.45[0.02; 11.15]11,399 -NAYoshihara (control unexposed, sick), 2012 1 case control studiescase control studies 1.47[0.32; 6.73]1,53412 -NAHowley, 2017 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.47[0.32; 6.73]1,53412 -NAHowley, 2017 1 unexposed, sickunexposed, sick 0.45[0.02; 11.15]11,399 -NAYoshihara (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 1.19[0.30; 4.68]1,5351,4110%NAHowley, 2017 Yoshihara (control unexposed, sick), 2012 2 All studiesAll studies 1.19[0.30; 4.68]1,5351,4110%NAHowley, 2017 Yoshihara (control unexposed, sick), 2012 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3355

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.47[0.32; 6.73]1,53412 -NAHowley, 2017 1 unexposed, sick controlsunexposed, sick controls Out of scale0.45[0.02; 11.15]11,399 -NAYoshihara (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.29[0.01; 7.20]11,399 -NAYoshihara (control exposed to MMI), 2012 10.510.01.0