Thiouracil, propylthiouracil, benzylthiouracil

Other congenital malformations (Q80 to Q99)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3366
R6161		 Seo (control exposed to MMI), 2018 Other (Q80–Q99) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.58 [0.27;1.23] C
excluded (control group) 		41/9,930   8/1,120 49 9,930
ref
S3367
R6173		 Seo (control unexposed, NOS), 2018 Other (Q80–Q99) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.14 [0.84;1.55] 41/9,930   10,023/2,872,109 10,064 9,930
ref
Total 1 studies 1.14 [0.84;1.55] 10,064 9,930
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Seo (control unexposed, NOS), 2018Seo, 2018 1 1.14[0.84; 1.55]10,0649,9300%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.14[0.84; 1.55]10,0649,930 -NASeo (control unexposed, NOS), 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.14[0.84; 1.55]10,0649,930 -NASeo (control unexposed, NOS), 2018 1 Tags Adjustment   - Yes  - Yes 1.14[0.84; 1.55]10,0649,930 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.14[0.84; 1.55]10,0649,930 -NASeo (control unexposed, NOS), 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3366

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.14[0.84; 1.55]10,0649,930 -NASeo (control unexposed, NOS), 2018 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.58[0.27; 1.23]499,930 -NASeo (control exposed to MMI), 2018 10.510.01.0