Thiouracil, propylthiouracil, benzylthiouracil

Coarctation of aorta

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
Howley, 2017 Coarctation of the aorta 1st trimester case control unexposed, disease free Adjustment: No 7.97 [1.58;37.10] 4/14   1,133/12,423 1,137 14
Total 1 studies 7.97 [1.64;38.62] 1,137 14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Howley, 2017Howley, 2017 7.97[1.58; 37.10]1,137140%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 7.97[1.64; 38.62]1,13714 -NAHowley, 2017 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 7.97[1.64; 38.62]1,13714 -NAHowley, 2017 1 Tags Adjustment   - No  - No 7.97[1.64; 38.62]1,13714 -NAHowley, 2017 1 All studiesAll studies 7.97[1.64; 38.62]1,13714 -NAHowley, 2017 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies


Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 7.97[1.64; 38.62]1,13714 -NAHowley, 2017 10.510.01.0